
Clonazepam (0.25mg) + Escitalopram Oxalate (5mg)
Active composition
+1 more active ingredient
Clonazepam enhances GABAergic neurotransmission by binding to GABA-A receptors, leading to increased inhibitory effects on neuronal excitability.
Medical applications
Leadpram-LS Tablet is a combination pharmaceutical formulation containing Clonazepam 0.25 mg and Escitalopram Oxalate 5 mg, indicated for the management of anxiety disorders, panic attacks, and depressive episodes associated with anxiety. Clonazepam, a benzodiazepine derivative, exerts its therapeutic effect by enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system, thereby producing anxiolytic, anticonvulsant, and muscle relaxant properties. Escitalopram Oxalate, a selective serotonin reuptake inhibitor (SSRI), increases serotonin levels in the synaptic cleft by inhibiting its reuptake, contributing to improved mood and reduced anxiety symptoms. The synergistic action of these two agents provides both rapid anxiolytic effects and sustained antidepressant benefits, making Leadpram-LS suitable for patients requiring comprehensive management of anxiety and depressive symptoms. It is essential to use this medication under strict medical supervision due to potential side effects such as drowsiness, dizziness, gastrointestinal disturbances, and the risk of dependence associated with clonazepam. Dose adjustments may be necessary in hepatic or renal impairment. Patients should avoid alcohol and other CNS depressants during therapy. Leadpram-LS should be prescribed after a thorough clinical evaluation, considering contraindications and potential drug interactions.
How to use Leadpram Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leadpram-LS Tablet may be taken with or without food, but it is better to take it at a fixed time.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
It is unsafe to consume alcohol with Leadpram-LS Tablet.
High Risk
Leadpram-LS Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Medical Advice
Leadpram-LS Tablet may cause side effects which could affect your ability to drive.
Exercise Caution
Leadpram-LS Tablet should be used with caution in patients with liver disease. Dose adjustment of Leadpram-LS Tablet may be needed. Please consult your doctor.
Regular Checkup
Leadpram-LS Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Leadpram-LS Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Leadpram-LS Tablet may not be needed in these patients. Please consult your doctor. Use of Leadpram-LS Tablet can cause excessive sleepiness in patients with end stage kidney disease.
Regular Checkup
0 reviews for Leadpram-LS Tablet

Clonazepam (0.25mg) + Escitalopram Oxalate (5mg)
Cheaper alternative availability
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Active composition
+1 more active ingredient
Clonazepam enhances GABAergic neurotransmission by binding to GABA-A receptors, leading to increased inhibitory effects on neuronal excitability.
Medical applications
Leadpram-LS Tablet is a combination pharmaceutical formulation containing Clonazepam 0.25 mg and Escitalopram Oxalate 5 mg, indicated for the management of anxiety disorders, panic attacks, and depressive episodes associated with anxiety. Clonazepam, a benzodiazepine derivative, exerts its therapeutic effect by enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system, thereby producing anxiolytic, anticonvulsant, and muscle relaxant properties. Escitalopram Oxalate, a selective serotonin reuptake inhibitor (SSRI), increases serotonin levels in the synaptic cleft by inhibiting its reuptake, contributing to improved mood and reduced anxiety symptoms. The synergistic action of these two agents provides both rapid anxiolytic effects and sustained antidepressant benefits, making Leadpram-LS suitable for patients requiring comprehensive management of anxiety and depressive symptoms. It is essential to use this medication under strict medical supervision due to potential side effects such as drowsiness, dizziness, gastrointestinal disturbances, and the risk of dependence associated with clonazepam. Dose adjustments may be necessary in hepatic or renal impairment. Patients should avoid alcohol and other CNS depressants during therapy. Leadpram-LS should be prescribed after a thorough clinical evaluation, considering contraindications and potential drug interactions.
How to use Leadpram Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leadpram-LS Tablet may be taken with or without food, but it is better to take it at a fixed time.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
It is unsafe to consume alcohol with Leadpram-LS Tablet.
High Risk
Leadpram-LS Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Medical Advice
Leadpram-LS Tablet may cause side effects which could affect your ability to drive.
Exercise Caution
Leadpram-LS Tablet should be used with caution in patients with liver disease. Dose adjustment of Leadpram-LS Tablet may be needed. Please consult your doctor.
Regular Checkup
Leadpram-LS Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Leadpram-LS Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Leadpram-LS Tablet may not be needed in these patients. Please consult your doctor. Use of Leadpram-LS Tablet can cause excessive sleepiness in patients with end stage kidney disease.
Regular Checkup
0 reviews for Leadpram-LS Tablet















