
Nifedipine (0.3% w/w) + Lidocaine (1.5% w/w)
Active composition
+1 more active ingredient
Nifedipine inhibits L-type calcium channels in vascular smooth muscle, leading to vasodilation and reduced blood pressure.
Lidocaine blocks sodium channels in nerve membranes, preventing the initiation and conduction of nerve impulses.
Medical applications
Fisofine Cream is a topical formulation containing Lidocaine (1.5% w/w) and Nifedipine (0.3% w/w), designed to provide effective relief from localized pain and discomfort associated with various dermatological and vascular conditions. Lidocaine, a well-known local anesthetic, works by blocking sodium channels in nerve cells, thereby inhibiting the initiation and conduction of nerve impulses, which results in rapid pain relief and numbness at the application site. Nifedipine, a calcium channel blocker, promotes vasodilation by relaxing the smooth muscles of blood vessels, improving blood flow and reducing symptoms related to vascular constriction such as ischemia and inflammation. The combination of these two active ingredients makes Fisofine Cream particularly useful in managing conditions like anal fissures, hemorrhoids, and other localized painful vascular disorders, where both pain control and improved circulation are essential for healing. The cream is applied topically to the affected area, allowing for targeted action with minimal systemic absorption, reducing the risk of systemic side effects. Fisofine Cream should be used as directed by a healthcare professional, and patients are advised to avoid contact with eyes and mucous membranes. It is suitable for adults and should be stored in a cool, dry place away from direct sunlight.
How to use Fisofine Rectal Cream This medicine is for external use only. Use it in the dose and duration as advised by your doctor.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
No interaction found/established
High Risk
Fisofine Cream may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
No interaction found/established
Exercise Caution
Fisofine Cream should be used with caution in patients with liver disease. Dose adjustment of Fisofine Cream may be needed. Please consult your doctor.
Regular Checkup
Fisofine Cream is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Fisofine Cream should be used with caution in patients with severe kidney disease. Dose adjustment of Fisofine Cream may be needed. Please consult your doctor.
Regular Checkup
0 reviews for Fisofine Cream

Lidocaine (1.5% w/w) + Nifedipine (0.3% w/w)
Cheaper alternative availability
This medicine doesn't have a cheaper alternative with the same composition. Our health advisors can help you find other savings options based on your prescription.
Active composition
+1 more active ingredient
Nifedipine inhibits L-type calcium channels in vascular smooth muscle, leading to vasodilation and reduced blood pressure.
Lidocaine blocks sodium channels in nerve membranes, preventing the initiation and conduction of nerve impulses.
Medical applications
Fisofine Cream is a topical formulation containing Lidocaine (1.5% w/w) and Nifedipine (0.3% w/w), designed to provide effective relief from localized pain and discomfort associated with various dermatological and vascular conditions. Lidocaine, a well-known local anesthetic, works by blocking sodium channels in nerve cells, thereby inhibiting the initiation and conduction of nerve impulses, which results in rapid pain relief and numbness at the application site. Nifedipine, a calcium channel blocker, promotes vasodilation by relaxing the smooth muscles of blood vessels, improving blood flow and reducing symptoms related to vascular constriction such as ischemia and inflammation. The combination of these two active ingredients makes Fisofine Cream particularly useful in managing conditions like anal fissures, hemorrhoids, and other localized painful vascular disorders, where both pain control and improved circulation are essential for healing. The cream is applied topically to the affected area, allowing for targeted action with minimal systemic absorption, reducing the risk of systemic side effects. Fisofine Cream should be used as directed by a healthcare professional, and patients are advised to avoid contact with eyes and mucous membranes. It is suitable for adults and should be stored in a cool, dry place away from direct sunlight.
How to use Fisofine Rectal Cream This medicine is for external use only. Use it in the dose and duration as advised by your doctor.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
No interaction found/established
High Risk
Fisofine Cream may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
No interaction found/established
Exercise Caution
Fisofine Cream should be used with caution in patients with liver disease. Dose adjustment of Fisofine Cream may be needed. Please consult your doctor.
Regular Checkup
Fisofine Cream is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Fisofine Cream should be used with caution in patients with severe kidney disease. Dose adjustment of Fisofine Cream may be needed. Please consult your doctor.
Regular Checkup
0 reviews for Fisofine Cream















