Macitentan is an endothelin receptor antagonist used to treat pulmonary arterial hypertension (PAH). It works by blocking the action of endothelin, a substance that constricts blood vessels, thereby relaxing the blood vessels and improving blood flow to the lungs. This medication can enhance exercise capacity and improve the quality of life in patients with PAH. Common side effects may include headaches and swelling, but these typically resolve over time. In summary, Macitentan is effective in managing high blood pressure in the lungs.
Macitentan selectively blocks endothelin-1 receptors, leading to vasodilation and reduced pulmonary vascular resistance.