
Flunarizine (10mg) + Propranolol (40mg)
Active composition
+1 more active ingredient
Flunarizine acts as a calcium channel blocker, preventing vasodilation and reducing the frequency of migraine attacks.
Propranolol blocks beta-1 and beta-2 adrenergic receptors, resulting in decreased heart rate, myocardial contractility, and overall cardiac output.
Medical applications
Mgrain Plus 10 Tablet SR is a sustained-release formulation of a fixed-dose combination of Propranolol 40mg and Flunarizine 10mg, indicated for the prophylactic treatment of migraine and cluster headache. Propranolol, a non-selective beta-blocker, exhibits anti-migraine properties by reducing vasospasm and inhibiting platelet aggregation, while Flunarizine, a calcium channel blocker, selectively inhibits the activation of voltage-gated calcium channels in neurons, thereby diminishing the release of pain-producing neurotransmitters. The sustained-release mechanism of Mgrain Plus 10 Tablet SR ensures a steady and prolonged release of the active ingredients, providing a consistent therapeutic effect over an extended period. This combination product is particularly useful for patients who require both beta-blockade and calcium channel blockade for the prevention of migraines. The tablet is designed to be taken once daily, allowing for a convenient and predictable treatment regimen.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Mgrain Plus 10 Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Information regarding the use of Mgrain Plus 10 Tablet SR during breastfeeding is not available. Please consult your doctor.
Medical Advice
Mgrain Plus 10 Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Mgrain Plus 10 Tablet SR may be needed. Please consult your doctor.
Exercise Caution
It is not known whether Mgrain Plus 10 Tablet SR alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Consult Doctor
Mgrain Plus 10 Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Mgrain Plus 10 Tablet SR may be needed. Please consult your doctor. Regular monitoring of blood pressure is advisable for dose adjustment.
Regular Checkup
0 reviews for Mgrain Plus 10 Tablet SR

Propranolol (40mg) + Flunarizine (10mg)
Cheaper alternative availability
This medicine doesn't have a cheaper alternative with the same composition. Our health advisors can help you find other savings options based on your prescription.
Active composition
+1 more active ingredient
Flunarizine acts as a calcium channel blocker, preventing vasodilation and reducing the frequency of migraine attacks.
Propranolol blocks beta-1 and beta-2 adrenergic receptors, resulting in decreased heart rate, myocardial contractility, and overall cardiac output.
Medical applications
Mgrain Plus 10 Tablet SR is a sustained-release formulation of a fixed-dose combination of Propranolol 40mg and Flunarizine 10mg, indicated for the prophylactic treatment of migraine and cluster headache. Propranolol, a non-selective beta-blocker, exhibits anti-migraine properties by reducing vasospasm and inhibiting platelet aggregation, while Flunarizine, a calcium channel blocker, selectively inhibits the activation of voltage-gated calcium channels in neurons, thereby diminishing the release of pain-producing neurotransmitters. The sustained-release mechanism of Mgrain Plus 10 Tablet SR ensures a steady and prolonged release of the active ingredients, providing a consistent therapeutic effect over an extended period. This combination product is particularly useful for patients who require both beta-blockade and calcium channel blockade for the prevention of migraines. The tablet is designed to be taken once daily, allowing for a convenient and predictable treatment regimen.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Mgrain Plus 10 Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Information regarding the use of Mgrain Plus 10 Tablet SR during breastfeeding is not available. Please consult your doctor.
Medical Advice
Mgrain Plus 10 Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Mgrain Plus 10 Tablet SR may be needed. Please consult your doctor.
Exercise Caution
It is not known whether Mgrain Plus 10 Tablet SR alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Consult Doctor
Mgrain Plus 10 Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Mgrain Plus 10 Tablet SR may be needed. Please consult your doctor. Regular monitoring of blood pressure is advisable for dose adjustment.
Regular Checkup
0 reviews for Mgrain Plus 10 Tablet SR















