
Serratiopeptidase (15mg) + Aceclofenac (100mg) + Paracetamol (325mg)
Active composition
+2 more active ingredients
Serratiopeptidase acts as a proteolytic enzyme, breaking down fibrin and other proteins involved in inflammation, thereby reducing pain and swelling.
Aceclofenac inhibits COX-1 and COX-2 enzymes, leading to decreased synthesis of prostaglandins, which are responsible for pain and inflammation.
Paracetamol works by inhibiting cyclooxygenase (COX) enzymes, leading to reduced synthesis of prostaglandins in the brain, which are responsible for pain and fever.
Medical applications
Makdol-SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 15 mg. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), provides effective relief from pain and inflammation by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol acts as an analgesic and antipyretic, alleviating mild to moderate pain and reducing fever through central inhibition of prostaglandin synthesis. Serratiopeptidase, a proteolytic enzyme, enhances the anti-inflammatory effect by breaking down inflammatory mediators and promoting the resolution of edema and swelling. This synergistic combination is indicated for the management of musculoskeletal disorders, postoperative pain, dental pain, and other inflammatory conditions. Makdol-SP Tablet offers rapid and sustained relief from pain and inflammation while improving tissue healing. It is generally well tolerated; however, caution is advised in patients with gastrointestinal ulcers, hepatic or renal impairment, and hypersensitivity to NSAIDs or any component of the formulation. The medication should be used under medical supervision, with adherence to prescribed dosage to minimize adverse effects such as gastrointestinal discomfort, allergic reactions, or hepatic dysfunction. Makdol-SP Tablet represents an effective therapeutic option for multimodal pain management in clinical practice.
How to use Makdol-SP Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Makdol-SP Tablet is to be taken with food.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
It is unsafe to consume alcohol with Makdol-SP Tablet.
High Risk
Makdol-SP Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
Makdol-SP Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Exercise Caution
Makdol-SP Tablet should be used with caution in patients with liver disease. Dose adjustment of Makdol-SP Tablet may be needed. Please consult your doctor. However, the use of Makdol-SP Tablet is not recommended in patients with severe liver disease and active liver disease.
Regular Checkup
Information regarding the use of Makdol-SP Tablet during breastfeeding is not available. Please consult your doctor.
Consult Doctor
Makdol-SP Tablet should be used with caution in patients with kidney disease. Dose adjustment of Makdol-SP Tablet may be needed. Please consult your doctor. Use of Makdol-SP Tablet is not recommended in patients with severe kidney disease.
Regular Checkup
0 reviews for Makdol-SP Tablet

Aceclofenac (100mg) + Paracetamol (325mg) + Serratiopeptidase (15mg)
Cheaper alternative availability
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Active composition
+2 more active ingredients
Serratiopeptidase acts as a proteolytic enzyme, breaking down fibrin and other proteins involved in inflammation, thereby reducing pain and swelling.
Aceclofenac inhibits COX-1 and COX-2 enzymes, leading to decreased synthesis of prostaglandins, which are responsible for pain and inflammation.
Paracetamol works by inhibiting cyclooxygenase (COX) enzymes, leading to reduced synthesis of prostaglandins in the brain, which are responsible for pain and fever.
Medical applications
Makdol-SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 15 mg. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), provides effective relief from pain and inflammation by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol acts as an analgesic and antipyretic, alleviating mild to moderate pain and reducing fever through central inhibition of prostaglandin synthesis. Serratiopeptidase, a proteolytic enzyme, enhances the anti-inflammatory effect by breaking down inflammatory mediators and promoting the resolution of edema and swelling. This synergistic combination is indicated for the management of musculoskeletal disorders, postoperative pain, dental pain, and other inflammatory conditions. Makdol-SP Tablet offers rapid and sustained relief from pain and inflammation while improving tissue healing. It is generally well tolerated; however, caution is advised in patients with gastrointestinal ulcers, hepatic or renal impairment, and hypersensitivity to NSAIDs or any component of the formulation. The medication should be used under medical supervision, with adherence to prescribed dosage to minimize adverse effects such as gastrointestinal discomfort, allergic reactions, or hepatic dysfunction. Makdol-SP Tablet represents an effective therapeutic option for multimodal pain management in clinical practice.
How to use Makdol-SP Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Makdol-SP Tablet is to be taken with food.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
It is unsafe to consume alcohol with Makdol-SP Tablet.
High Risk
Makdol-SP Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
Makdol-SP Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Exercise Caution
Makdol-SP Tablet should be used with caution in patients with liver disease. Dose adjustment of Makdol-SP Tablet may be needed. Please consult your doctor. However, the use of Makdol-SP Tablet is not recommended in patients with severe liver disease and active liver disease.
Regular Checkup
Information regarding the use of Makdol-SP Tablet during breastfeeding is not available. Please consult your doctor.
Consult Doctor
Makdol-SP Tablet should be used with caution in patients with kidney disease. Dose adjustment of Makdol-SP Tablet may be needed. Please consult your doctor. Use of Makdol-SP Tablet is not recommended in patients with severe kidney disease.
Regular Checkup
0 reviews for Makdol-SP Tablet











