Macsita 50 Tablet
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Sitagliptin (50mg)
Strip of 10 tablets • Tablet
A valid prescription is required for this medicine.
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Active composition
Sitagliptin inhibits DPP-4, increasing incretin levels, which stimulate insulin release and reduce glucagon secretion.
Medical applications
Macsita 50 Tablet contains Sitagliptin 50 mg, an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors, which work by enhancing the body's incretin system. This mechanism increases insulin release from pancreatic beta cells and decreases glucagon secretion from alpha cells in a glucose-dependent manner, thereby improving glycemic control without causing significant hypoglycemia.
Macsita 50 is indicated as monotherapy or as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes, and it may be used in combination with other antidiabetic agents such as metformin or sulfonylureas. The usual dosage is one tablet taken orally once daily, with or without food. Sitagliptin is generally well tolerated; however, patients should be monitored for potential adverse effects including hypersensitivity reactions, pancreatitis, and signs of renal impairment.
Dose adjustments may be necessary in patients with moderate to severe renal dysfunction. Macsita 50 should be used as part of a comprehensive diabetes management plan including lifestyle modifications to achieve optimal therapeutic outcomes.
Pyrazine-derivative
Important precautions
Side-effect information is not available for this medicine. Please consult your doctor or pharmacist.
Information regarding the use of Macsita 50 Tablet during pregnancy is not available. Please consult your doctor.
High Risk
Macsita 50 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medical Advice
Macsita 50 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Macsita 50 Tablet may be needed. Please consult your doctor.
Exercise Caution
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Consult Doctor
Macsita 50 Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Macsita 50 Tablet may not be needed in these patients. Please consult your doctor. However, Macsita 50 Tablet has not been studied in patients with severe hepatic impairment and is not recommended for use in such patients.
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