Macox Plus 600 Tablet
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1 units • OtherPrescription requiredSchedule H
Macox Plus 600 Tablet
Rifampicin (600mg) + Isoniazid (300mg)
₹101.68
1 units • Other
A valid prescription is required for this medicine.
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Active composition
Isoniazid 300 mg
+1 more active ingredient
How It Works
Isoniazid inhibits the enzyme responsible for mycolic acid synthesis, disrupting bacterial cell wall formation and leading to cell death.
Rifampicin inhibits bacterial RNA polymerase, preventing transcription and leading to bacterial cell death.
Medicine Strength
300 mg
All Active Ingredients
Isoniazid300 mg
Rifampicin600 mg
Uses & Benefits
Medical applications
BacterialNausea
Macox Plus 600 Tablet is a combination antimicrobial medication containing Rifampicin 600 mg and Isoniazid 300 mg, primarily indicated for the treatment of tuberculosis (TB). Rifampicin acts by inhibiting DNA-dependent RNA polymerase in Mycobacterium tuberculosis, thereby suppressing RNA synthesis and bacterial replication. Isoniazid exerts its bactericidal effect by inhibiting the synthesis of mycolic acids, essential components of the mycobacterial cell wall.
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The synergistic action of these agents enhances therapeutic efficacy and reduces the risk of drug resistance. Macox Plus 600 is typically administered as part of a multi-drug regimen under strict medical supervision, with dosing tailored according to patient weight, disease severity, and treatment response. Common adverse effects include hepatotoxicity, peripheral neuropathy, gastrointestinal disturbances, and hypersensitivity reactions; therefore, liver function tests and neurological assessments are recommended during therapy.
Patients should be advised to avoid alcohol and report any signs of jaundice, persistent nausea, or unusual fatigue promptly. This combination is contraindicated in patients with known hypersensitivity to rifampicin or isoniazid and should be used cautiously in individuals with pre-existing liver disease. Macox Plus 600 Tablet is a critical component in the effective management of tuberculosis, contributing to improved patient outcomes when used appropriately.
Dosage & How to Use
Dosage information not available. Please consult your doctor or pharmacist.
Safety Advice
Important precautions
Side effects
Side-effect information is not available for this medicine. Please consult your doctor or pharmacist.
Safety Advice
Alcohol
Macox Plus 600 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Pregnancy
Macox Plus 600 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Medical Advice
Driving
Macox Plus 600 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Macox Plus 600 Tablet may be needed. Please consult your doctor.
Exercise Caution
Breastfeeding
Macox Plus 600 Tablet may cause side effects which could affect your ability to drive. Macox Plus 600 Tablet can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
Consult Doctor
Kidney
Macox Plus 600 Tablet should be used with caution in patients with liver disease. Dose adjustment of Macox Plus 600 Tablet may be needed. Please consult your doctor. Use of Macox Plus 600 Tablet is not recommended in patients with severe liver disease.
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