Januvia 50mg Tablet
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Sitagliptin (50mg)
Strip of 7 tablets • Tablet
A valid prescription is required for this medicine.
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Active composition
Sitagliptin inhibits DPP-4, increasing incretin levels, which stimulate insulin release and reduce glucagon secretion.
Medical applications
Januvia 50mg Tablet contains Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated for the management of type 2 diabetes mellitus. Sitagliptin works by enhancing the levels of incretin hormones, which increase insulin release from pancreatic beta cells and decrease glucagon secretion from alpha cells in a glucose-dependent manner, thereby improving glycemic control.
Januvia is prescribed as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes, either as monotherapy or in combination with other antidiabetic agents such as metformin, sulfonylureas, or insulin. The recommended dose is 50mg once daily, with or without food. It is important to monitor renal function prior to initiation and periodically during therapy, as dose adjustments may be necessary in patients with renal impairment.
Common adverse effects include nasopharyngitis, headache, and upper respiratory tract infections, while hypoglycemia risk increases when used with sulfonylureas or insulin. Januvia is contraindicated in patients with type 1 diabetes or diabetic ketoacidosis. Caution is advised in patients with a history of pancreatitis. Overall, Januvia offers a convenient and effective option for improving glycemic control in type 2 diabetes patients.
Pyrazine-derivative
Important precautions
Side-effect information is not available for this medicine. Please consult your doctor or pharmacist.
Information regarding the use of Januvia 50mg Tablet during pregnancy is not available. Please consult your doctor.
High Risk
Januvia 50mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medical Advice
Januvia 50mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Januvia 50mg Tablet may be needed. Please consult your doctor.
Exercise Caution
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Consult Doctor
Januvia 50mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Januvia 50mg Tablet may not be needed in these patients. Please consult your doctor. However, Januvia 50mg Tablet has not been studied in patients with severe hepatic impairment and is not recommended for use in such patients.
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