
Domperidone (10mg) + Naproxen (500mg)
Active composition
+1 more active ingredient
Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, inhibiting nausea and vomiting.
Naproxen inhibits COX-1 and COX-2 enzymes, decreasing the production of inflammatory mediators.
Medical applications
Headmedi-N 500 Tablet is a combination medication containing Naproxen 500 mg and Domperidone 10 mg, formulated to provide effective relief from pain and associated gastrointestinal discomfort. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), exerts analgesic, anti-inflammatory, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Domperidone, a dopamine D2 receptor antagonist, enhances gastrointestinal motility and accelerates gastric emptying, helping to alleviate nausea and vomiting often associated with pain or NSAID therapy. This combination is particularly useful in managing conditions such as musculoskeletal pain, headaches, dental pain, and dysmenorrhea where inflammation and gastrointestinal side effects coexist. Headmedi-N 500 Tablet should be used under medical supervision, especially in patients with a history of gastrointestinal ulcers, cardiovascular disease, or hepatic and renal impairment. Common adverse effects may include gastrointestinal discomfort, dizziness, and dry mouth. It is contraindicated in patients with known hypersensitivity to either component and should be used with caution during pregnancy and lactation. Proper dosing and adherence to prescribed duration are essential to minimize risks and ensure therapeutic efficacy.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Headmedi-N 500 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Headmedi-N 500 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Medical Advice
Headmedi-N 500 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Headmedi-N 500 Tablet may be needed. Please consult your doctor.
Exercise Caution
Headmedi-N 500 Tablet may cause side effects which could affect your ability to drive. Headmedi-N 500 Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.
Consult Doctor
Headmedi-N 500 Tablet should be used with caution in patients with liver disease. Dose adjustment of Headmedi-N 500 Tablet may be needed. Please consult your doctor. Use of Headmedi-N 500 Tablet is not recommended in patients with moderate and severe liver disease.
Regular Checkup
0 reviews for Headmedi-N 500 Tablet

Naproxen (500mg) + Domperidone (10mg)
Cheaper alternative availability
This medicine doesn't have a cheaper alternative with the same composition. Our health advisors can help you find other savings options based on your prescription.
Active composition
+1 more active ingredient
Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, inhibiting nausea and vomiting.
Naproxen inhibits COX-1 and COX-2 enzymes, decreasing the production of inflammatory mediators.
Medical applications
Headmedi-N 500 Tablet is a combination medication containing Naproxen 500 mg and Domperidone 10 mg, formulated to provide effective relief from pain and associated gastrointestinal discomfort. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), exerts analgesic, anti-inflammatory, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Domperidone, a dopamine D2 receptor antagonist, enhances gastrointestinal motility and accelerates gastric emptying, helping to alleviate nausea and vomiting often associated with pain or NSAID therapy. This combination is particularly useful in managing conditions such as musculoskeletal pain, headaches, dental pain, and dysmenorrhea where inflammation and gastrointestinal side effects coexist. Headmedi-N 500 Tablet should be used under medical supervision, especially in patients with a history of gastrointestinal ulcers, cardiovascular disease, or hepatic and renal impairment. Common adverse effects may include gastrointestinal discomfort, dizziness, and dry mouth. It is contraindicated in patients with known hypersensitivity to either component and should be used with caution during pregnancy and lactation. Proper dosing and adherence to prescribed duration are essential to minimize risks and ensure therapeutic efficacy.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Headmedi-N 500 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Headmedi-N 500 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Medical Advice
Headmedi-N 500 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Headmedi-N 500 Tablet may be needed. Please consult your doctor.
Exercise Caution
Headmedi-N 500 Tablet may cause side effects which could affect your ability to drive. Headmedi-N 500 Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.
Consult Doctor
Headmedi-N 500 Tablet should be used with caution in patients with liver disease. Dose adjustment of Headmedi-N 500 Tablet may be needed. Please consult your doctor. Use of Headmedi-N 500 Tablet is not recommended in patients with moderate and severe liver disease.
Regular Checkup
0 reviews for Headmedi-N 500 Tablet















