
Naproxen (250mg) + Domperidone (10mg)
Active composition
+1 more active ingredient
Naproxen inhibits COX-1 and COX-2 enzymes, decreasing the production of inflammatory mediators.
Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, inhibiting nausea and vomiting.
Medical applications
Headmedi-N 250 Tablet is a combination medication containing Naproxen 250 mg and Domperidone 10 mg, formulated to provide effective relief from pain and associated gastrointestinal discomfort. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), exerts analgesic, anti-inflammatory, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis responsible for pain and inflammation. Domperidone, a dopamine D2 receptor antagonist, enhances gastrointestinal motility and accelerates gastric emptying, which helps alleviate nausea and vomiting often associated with pain or NSAID therapy. This combination is commonly prescribed for conditions such as musculoskeletal pain, dysmenorrhea, and inflammatory disorders where pain relief is required alongside management of gastrointestinal side effects. Headmedi-N 250 should be used under medical supervision, with caution advised in patients with a history of peptic ulcers, cardiovascular disease, or hepatic impairment. It is contraindicated in individuals with hypersensitivity to either component and should be avoided during pregnancy and lactation unless deemed necessary by a healthcare professional. Common adverse effects may include gastrointestinal discomfort, dizziness, and dry mouth. Patients are advised to follow prescribed dosages and report any unusual symptoms to their healthcare provider promptly.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Headmedi-N 250 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Headmedi-N 250 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Medical Advice
Headmedi-N 250 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Headmedi-N 250 Tablet may be needed. Please consult your doctor.
Exercise Caution
Headmedi-N 250 Tablet may cause side effects which could affect your ability to drive. Headmedi-N 250 Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.
Consult Doctor
Headmedi-N 250 Tablet should be used with caution in patients with liver disease. Dose adjustment of Headmedi-N 250 Tablet may be needed. Please consult your doctor. Use of Headmedi-N 250 Tablet is not recommended in patients with moderate and severe liver disease.
Regular Checkup
0 reviews for Headmedi-N 250 Tablet

Naproxen (250mg) + Domperidone (10mg)
Cheaper alternative availability
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Active composition
+1 more active ingredient
Naproxen inhibits COX-1 and COX-2 enzymes, decreasing the production of inflammatory mediators.
Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, inhibiting nausea and vomiting.
Medical applications
Headmedi-N 250 Tablet is a combination medication containing Naproxen 250 mg and Domperidone 10 mg, formulated to provide effective relief from pain and associated gastrointestinal discomfort. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), exerts analgesic, anti-inflammatory, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis responsible for pain and inflammation. Domperidone, a dopamine D2 receptor antagonist, enhances gastrointestinal motility and accelerates gastric emptying, which helps alleviate nausea and vomiting often associated with pain or NSAID therapy. This combination is commonly prescribed for conditions such as musculoskeletal pain, dysmenorrhea, and inflammatory disorders where pain relief is required alongside management of gastrointestinal side effects. Headmedi-N 250 should be used under medical supervision, with caution advised in patients with a history of peptic ulcers, cardiovascular disease, or hepatic impairment. It is contraindicated in individuals with hypersensitivity to either component and should be avoided during pregnancy and lactation unless deemed necessary by a healthcare professional. Common adverse effects may include gastrointestinal discomfort, dizziness, and dry mouth. Patients are advised to follow prescribed dosages and report any unusual symptoms to their healthcare provider promptly.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Headmedi-N 250 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Headmedi-N 250 Tablet is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Medical Advice
Headmedi-N 250 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Headmedi-N 250 Tablet may be needed. Please consult your doctor.
Exercise Caution
Headmedi-N 250 Tablet may cause side effects which could affect your ability to drive. Headmedi-N 250 Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.
Consult Doctor
Headmedi-N 250 Tablet should be used with caution in patients with liver disease. Dose adjustment of Headmedi-N 250 Tablet may be needed. Please consult your doctor. Use of Headmedi-N 250 Tablet is not recommended in patients with moderate and severe liver disease.
Regular Checkup
0 reviews for Headmedi-N 250 Tablet















