
Glimepiride (2mg) + Metformin (500mg)
Active composition
+1 more active ingredient
Glimepiride stimulates insulin secretion from pancreatic beta cells and enhances insulin sensitivity in peripheral tissues, facilitating glucose uptake and lowering blood sugar levels.
Metformin reduces hepatic glucose production and enhances peripheral insulin sensitivity, lowering blood glucose levels.
Medical applications
Glyshield G2 Tablet SR is a sustained-release oral hypoglycemic agent combining Glimepiride (2mg) and Metformin (500mg), indicated for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class drug, stimulates pancreatic beta cells to increase insulin secretion, thereby reducing blood glucose levels. Metformin, a biguanide, primarily decreases hepatic glucose production and improves peripheral insulin sensitivity, enhancing glucose uptake by muscle tissues. The sustained-release formulation ensures a gradual release of active ingredients, promoting stable glycemic control and minimizing gastrointestinal side effects commonly associated with immediate-release metformin. Glyshield G2 is prescribed as part of a comprehensive diabetes management plan that includes diet, exercise, and lifestyle modifications. It is particularly beneficial for patients inadequately controlled on monotherapy or those requiring combination therapy to achieve target glycemic levels. Caution is advised in patients with renal impairment, hepatic dysfunction, or conditions predisposing to lactic acidosis. Regular monitoring of blood glucose, renal function, and liver enzymes is recommended during therapy. Glyshield G2 should be used under medical supervision, with dose adjustments based on therapeutic response and tolerability. This combination therapy offers an effective approach to improving glycemic control in type 2 diabetes patients.
How to use Glyshield G Tablet SR Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glyshield G2 Tablet SR is to be taken with food.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
It is unsafe to consume alcohol with Glyshield G2 Tablet SR.
High Risk
Glyshield G2 Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Exercise Caution
Glyshield G2 Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Glyshield G2 Tablet SR may be needed. Please consult your doctor. Glyshield G2 Tablet SR is generally started with a low dose in patients with mild to moderate liver disease, and its use is not recommended in patients with severe liver disease.
Regular Checkup
Glyshield G2 Tablet SR is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Consult Doctor
Glyshield G2 Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Glyshield G2 Tablet SR may be needed. Please consult your doctor. Use of Glyshield G2 Tablet SR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function tests is advisable while you are taking this medicine.
Regular Checkup
0 reviews for Glyshield G2 Tablet SR

Glimepiride (2mg) + Metformin (500mg)
Cheaper alternative availability
This medicine doesn't have a cheaper alternative with the same composition. Our health advisors can help you find other savings options based on your prescription.
Active composition
+1 more active ingredient
Glimepiride stimulates insulin secretion from pancreatic beta cells and enhances insulin sensitivity in peripheral tissues, facilitating glucose uptake and lowering blood sugar levels.
Metformin reduces hepatic glucose production and enhances peripheral insulin sensitivity, lowering blood glucose levels.
Medical applications
Glyshield G2 Tablet SR is a sustained-release oral hypoglycemic agent combining Glimepiride (2mg) and Metformin (500mg), indicated for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class drug, stimulates pancreatic beta cells to increase insulin secretion, thereby reducing blood glucose levels. Metformin, a biguanide, primarily decreases hepatic glucose production and improves peripheral insulin sensitivity, enhancing glucose uptake by muscle tissues. The sustained-release formulation ensures a gradual release of active ingredients, promoting stable glycemic control and minimizing gastrointestinal side effects commonly associated with immediate-release metformin. Glyshield G2 is prescribed as part of a comprehensive diabetes management plan that includes diet, exercise, and lifestyle modifications. It is particularly beneficial for patients inadequately controlled on monotherapy or those requiring combination therapy to achieve target glycemic levels. Caution is advised in patients with renal impairment, hepatic dysfunction, or conditions predisposing to lactic acidosis. Regular monitoring of blood glucose, renal function, and liver enzymes is recommended during therapy. Glyshield G2 should be used under medical supervision, with dose adjustments based on therapeutic response and tolerability. This combination therapy offers an effective approach to improving glycemic control in type 2 diabetes patients.
How to use Glyshield G Tablet SR Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Glyshield G2 Tablet SR is to be taken with food.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
It is unsafe to consume alcohol with Glyshield G2 Tablet SR.
High Risk
Glyshield G2 Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Exercise Caution
Glyshield G2 Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Glyshield G2 Tablet SR may be needed. Please consult your doctor. Glyshield G2 Tablet SR is generally started with a low dose in patients with mild to moderate liver disease, and its use is not recommended in patients with severe liver disease.
Regular Checkup
Glyshield G2 Tablet SR is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Consult Doctor
Glyshield G2 Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Glyshield G2 Tablet SR may be needed. Please consult your doctor. Use of Glyshield G2 Tablet SR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function tests is advisable while you are taking this medicine.
Regular Checkup
0 reviews for Glyshield G2 Tablet SR













