Gliptagreat M 500 Tablet is a combination oral antidiabetic medication containing Metformin 500 mg and Vildagliptin 50 mg, indicated for the management of type 2 diabetes mellitus. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production, improving insulin sensitivity, and enhancing peripheral glucose uptake, thereby aiding in glycemic control without causing significant hypoglycemia. Vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, enhances the incretin system by preventing the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), resulting in increased insulin secretion and decreased glucagon release in a glucose-dependent manner. The combined pharmacologic actions of Gliptagreat M 500 provide complementary mechanisms to effectively reduce fasting and postprandial blood glucose levels. This combination therapy is recommended for patients inadequately controlled on metformin monotherapy or those for whom metformin and vildagliptin combination is appropriate. Gliptagreat M 500 should be used alongside diet and exercise to optimize glycemic control. Caution is advised in patients with renal impairment, hepatic dysfunction, or a history of lactic acidosis. Regular monitoring of blood glucose, renal function, and potential adverse effects such as gastrointestinal discomfort or hypoglycemia is essential during therapy.

Dosage & How to Use

Dosage information not available. Please consult your doctor or pharmacist.