Terlipressin is a vasopressin receptor agonist used to manage bleeding esophageal varices and treat type 1 hepatorenal syndrome in patients with liver cirrhosis. By constricting blood vessels, Terlipressin reduces blood flow to the portal circulation, thereby controlling bleeding. It also aids in improving renal function in patients with acute kidney injury related to liver disease. Common side effects may include abdominal cramps and changes in blood pressure, but these typically resolve over time. In simple terms, Terlipressin helps control bleeding in the esophagus and supports kidney function in liver disease.
Terlipressin activates V1 receptors on vascular smooth muscle, causing vasoconstriction and reducing portal pressure, which helps control bleeding from esophageal varices.