Decitabine is a hypomethylating agent used to treat myelodysplastic syndromes and acute myeloid leukemia. It works by incorporating into DNA and inhibiting DNA methyltransferase, leading to the reactivation of silenced genes and promoting the differentiation of abnormal cells in the bone marrow. This drug is administered intravenously and is crucial for managing certain blood cancers. Common side effects may include injection site reactions and fatigue, but these usually resolve over time. In summary, Decitabine is an important treatment for specific blood disorders.
Decitabine is incorporated into DNA, inhibiting DNA methyltransferase, leading to hypomethylation of genes and reactivation of tumor suppressor genes.