
Nortriptyline (10mg) + Methylcobalamin (1500mcg) + Pregabalin (75mg)
Active composition
+2 more active ingredients
Nortriptyline inhibits the reuptake of norepinephrine and serotonin, increasing their levels in the synaptic cleft and enhancing mood.
Methylcobalamin acts as a cofactor in the synthesis of methionine from homocysteine, promoting nerve health and red blood cell formation.
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, inhibiting excitatory neurotransmitter release and reducing neuronal excitability.
Medical applications
Methynerve Tablet SR is a sustained-release formulation combining Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated neurological conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channels to reduce neuronal excitability, thereby alleviating neuropathic pain and improving sleep quality. Nortriptyline, a tricyclic antidepressant, enhances noradrenergic and serotonergic neurotransmission, contributing to analgesic effects and mood stabilization in chronic pain states. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by promoting myelin sheath synthesis and neuronal metabolism. The combination in Methynerve Tablet SR offers a multimodal approach targeting pain relief, nerve healing, and psychological well-being, making it suitable for conditions such as diabetic neuropathy, postherpetic neuralgia, and peripheral neuropathies. The sustained-release mechanism ensures prolonged therapeutic plasma concentrations, improving patient compliance and minimizing dosing frequency. Methynerve Tablet SR should be used under medical supervision, with dosage adjustments based on clinical response and tolerability. Common adverse effects may include dizziness, dry mouth, sedation, and gastrointestinal disturbances. Caution is advised in patients with renal impairment, cardiac conditions, or those taking concomitant CNS depressants.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Methynerve Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Methynerve Tablet SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medical Advice
Methynerve Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Methynerve Tablet SR may be needed. Please consult your doctor.
Exercise Caution
Methynerve Tablet SR may cause side effects which could affect your ability to drive. As Methynerve Tablet SR may affect your alertness which may affect your ability to drive.
Consult Doctor
Methynerve Tablet SR is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Methynerve Tablet SR may not be needed in these patients. Please consult your doctor.
Regular Checkup
0 reviews for Methynerve Tablet SR

Pregabalin (75mg) + Nortriptyline (10mg) + Methylcobalamin (1500mcg)
Cheaper alternative availability
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Active composition
+2 more active ingredients
Nortriptyline inhibits the reuptake of norepinephrine and serotonin, increasing their levels in the synaptic cleft and enhancing mood.
Methylcobalamin acts as a cofactor in the synthesis of methionine from homocysteine, promoting nerve health and red blood cell formation.
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, inhibiting excitatory neurotransmitter release and reducing neuronal excitability.
Medical applications
Methynerve Tablet SR is a sustained-release formulation combining Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated neurological conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channels to reduce neuronal excitability, thereby alleviating neuropathic pain and improving sleep quality. Nortriptyline, a tricyclic antidepressant, enhances noradrenergic and serotonergic neurotransmission, contributing to analgesic effects and mood stabilization in chronic pain states. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by promoting myelin sheath synthesis and neuronal metabolism. The combination in Methynerve Tablet SR offers a multimodal approach targeting pain relief, nerve healing, and psychological well-being, making it suitable for conditions such as diabetic neuropathy, postherpetic neuralgia, and peripheral neuropathies. The sustained-release mechanism ensures prolonged therapeutic plasma concentrations, improving patient compliance and minimizing dosing frequency. Methynerve Tablet SR should be used under medical supervision, with dosage adjustments based on clinical response and tolerability. Common adverse effects may include dizziness, dry mouth, sedation, and gastrointestinal disturbances. Caution is advised in patients with renal impairment, cardiac conditions, or those taking concomitant CNS depressants.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Methynerve Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Methynerve Tablet SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medical Advice
Methynerve Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Methynerve Tablet SR may be needed. Please consult your doctor.
Exercise Caution
Methynerve Tablet SR may cause side effects which could affect your ability to drive. As Methynerve Tablet SR may affect your alertness which may affect your ability to drive.
Consult Doctor
Methynerve Tablet SR is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Methynerve Tablet SR may not be needed in these patients. Please consult your doctor.
Regular Checkup
0 reviews for Methynerve Tablet SR















