
Hydrocortisone (1% w/w) + Hydroquinone (2% w/w) + Tretinoin (0.025% w/w)
Active composition
+2 more active ingredients
Hydrocortisone binds to glucocorticoid receptors, modulating gene expression and inhibiting inflammatory response.
Hydroquinone inhibits the enzyme tyrosinase, reducing melanin synthesis and lightening hyperpigmented skin.
Tretinoin increases cell turnover and decreases sebum production, preventing the formation of acne lesions.
Medical applications
Melanorm-HC Cream is a topical formulation combining Hydroquinone (2% w/w), Tretinoin (0.025% w/w), and Hydrocortisone (1% w/w) designed for the treatment of hyperpigmentation disorders such as melasma, freckles, and post-inflammatory hyperpigmentation. Hydroquinone acts as a skin-lightening agent by inhibiting tyrosinase, an enzyme critical in melanin synthesis, thereby reducing excessive pigmentation. Tretinoin, a retinoid, promotes epidermal cell turnover and enhances the penetration of hydroquinone, facilitating more effective pigment dispersion and skin renewal. Hydrocortisone, a mild corticosteroid, helps to mitigate inflammation and irritation commonly associated with hydroquinone and tretinoin use, improving patient tolerability. Melanorm-HC Cream should be applied once daily, preferably at night, to clean, dry skin on the affected areas. Patients are advised to use sunscreen and limit sun exposure during treatment to prevent further pigmentation and phototoxicity. The combination therapy is typically recommended for short-term use under medical supervision due to potential side effects such as skin irritation, redness, or steroid-related adverse effects. This product is contraindicated in individuals with hypersensitivity to any of its components, pregnant or lactating women, and those with pre-existing skin infections or conditions.
How to use Melanorm-HC Cream This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
No interaction found/established
High Risk
Information regarding the use of Melanorm-HC Cream during pregnancy is not available. Please consult your doctor.
Medical Advice
No interaction found/established
Exercise Caution
No interaction found/established
Regular Checkup
Information regarding the use of Melanorm-HC Cream during breastfeeding is not available. Please consult your doctor.
Consult Doctor
No interaction found/established
Regular Checkup
0 reviews for Melanorm-HC Cream

Hydroquinone (2% w/w) + Tretinoin (0.025% w/w) + Hydrocortisone (1% w/w)
Cheaper alternative availability
This medicine doesn't have a cheaper alternative with the same composition. Our health advisors can help you find other savings options based on your prescription.
Active composition
+2 more active ingredients
Hydrocortisone binds to glucocorticoid receptors, modulating gene expression and inhibiting inflammatory response.
Hydroquinone inhibits the enzyme tyrosinase, reducing melanin synthesis and lightening hyperpigmented skin.
Tretinoin increases cell turnover and decreases sebum production, preventing the formation of acne lesions.
Medical applications
Melanorm-HC Cream is a topical formulation combining Hydroquinone (2% w/w), Tretinoin (0.025% w/w), and Hydrocortisone (1% w/w) designed for the treatment of hyperpigmentation disorders such as melasma, freckles, and post-inflammatory hyperpigmentation. Hydroquinone acts as a skin-lightening agent by inhibiting tyrosinase, an enzyme critical in melanin synthesis, thereby reducing excessive pigmentation. Tretinoin, a retinoid, promotes epidermal cell turnover and enhances the penetration of hydroquinone, facilitating more effective pigment dispersion and skin renewal. Hydrocortisone, a mild corticosteroid, helps to mitigate inflammation and irritation commonly associated with hydroquinone and tretinoin use, improving patient tolerability. Melanorm-HC Cream should be applied once daily, preferably at night, to clean, dry skin on the affected areas. Patients are advised to use sunscreen and limit sun exposure during treatment to prevent further pigmentation and phototoxicity. The combination therapy is typically recommended for short-term use under medical supervision due to potential side effects such as skin irritation, redness, or steroid-related adverse effects. This product is contraindicated in individuals with hypersensitivity to any of its components, pregnant or lactating women, and those with pre-existing skin infections or conditions.
How to use Melanorm-HC Cream This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
No interaction found/established
High Risk
Information regarding the use of Melanorm-HC Cream during pregnancy is not available. Please consult your doctor.
Medical Advice
No interaction found/established
Exercise Caution
No interaction found/established
Regular Checkup
Information regarding the use of Melanorm-HC Cream during breastfeeding is not available. Please consult your doctor.
Consult Doctor
No interaction found/established
Regular Checkup
0 reviews for Melanorm-HC Cream















