
Nortriptyline (10mg) + Pregabalin (75mg) + Methylcobalamin (1500mcg)
Active composition
+2 more active ingredients
Nortriptyline inhibits the reuptake of norepinephrine and serotonin, increasing their levels in the synaptic cleft and enhancing mood.
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, inhibiting excitatory neurotransmitter release and reducing neuronal excitability.
Methylcobalamin acts as a cofactor in the synthesis of methionine from homocysteine, promoting nerve health and red blood cell formation.
Medical applications
Mecobion-NP Tablet SR is a sustained-release formulation combining Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated neurological conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channel function to reduce neurotransmitter release, thereby alleviating neuropathic pain and improving nerve function. Nortriptyline, a tricyclic antidepressant, exerts analgesic effects through inhibition of norepinephrine and serotonin reuptake, enhancing descending inhibitory pain pathways and providing mood stabilization. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by promoting myelin sheath synthesis and neuronal metabolism. The sustained-release formulation ensures prolonged therapeutic plasma levels, improving patient compliance and minimizing dosing frequency. Mecobion-NP is indicated for diabetic neuropathy, postherpetic neuralgia, peripheral neuropathies, and other chronic neuropathic pain syndromes. It is essential to administer this medication under medical supervision, considering potential side effects such as dizziness, dry mouth, sedation, and gastrointestinal disturbances. Caution is advised in patients with renal impairment, cardiac conditions, or a history of seizures. Regular monitoring and dose adjustments may be necessary to optimize therapeutic outcomes while minimizing adverse effects. Mecobion-NP Tablet SR offers a multimodal approach for effective neuropathic pain management and nerve health restoration.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Mecobion-NP Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Mecobion-NP Tablet SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medical Advice
Mecobion-NP Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Mecobion-NP Tablet SR may be needed. Please consult your doctor.
Exercise Caution
Mecobion-NP Tablet SR may cause side effects which could affect your ability to drive. As Mecobion-NP Tablet SR may affect your alertness which may affect your ability to drive.
Consult Doctor
Mecobion-NP Tablet SR is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Mecobion-NP Tablet SR may not be needed in these patients. Please consult your doctor.
Regular Checkup
0 reviews for Mecobion-NP Tablet SR

Pregabalin (75mg) + Nortriptyline (10mg) + Methylcobalamin (1500mcg)
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Active composition
+2 more active ingredients
Nortriptyline inhibits the reuptake of norepinephrine and serotonin, increasing their levels in the synaptic cleft and enhancing mood.
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, inhibiting excitatory neurotransmitter release and reducing neuronal excitability.
Methylcobalamin acts as a cofactor in the synthesis of methionine from homocysteine, promoting nerve health and red blood cell formation.
Medical applications
Mecobion-NP Tablet SR is a sustained-release formulation combining Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated neurological conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channel function to reduce neurotransmitter release, thereby alleviating neuropathic pain and improving nerve function. Nortriptyline, a tricyclic antidepressant, exerts analgesic effects through inhibition of norepinephrine and serotonin reuptake, enhancing descending inhibitory pain pathways and providing mood stabilization. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by promoting myelin sheath synthesis and neuronal metabolism. The sustained-release formulation ensures prolonged therapeutic plasma levels, improving patient compliance and minimizing dosing frequency. Mecobion-NP is indicated for diabetic neuropathy, postherpetic neuralgia, peripheral neuropathies, and other chronic neuropathic pain syndromes. It is essential to administer this medication under medical supervision, considering potential side effects such as dizziness, dry mouth, sedation, and gastrointestinal disturbances. Caution is advised in patients with renal impairment, cardiac conditions, or a history of seizures. Regular monitoring and dose adjustments may be necessary to optimize therapeutic outcomes while minimizing adverse effects. Mecobion-NP Tablet SR offers a multimodal approach for effective neuropathic pain management and nerve health restoration.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Based on clinical trials and patient reports.
Overall Tolerance
Common Side Effects
Mecobion-NP Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
Mecobion-NP Tablet SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medical Advice
Mecobion-NP Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Mecobion-NP Tablet SR may be needed. Please consult your doctor.
Exercise Caution
Mecobion-NP Tablet SR may cause side effects which could affect your ability to drive. As Mecobion-NP Tablet SR may affect your alertness which may affect your ability to drive.
Consult Doctor
Mecobion-NP Tablet SR is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Mecobion-NP Tablet SR may not be needed in these patients. Please consult your doctor.
Regular Checkup
0 reviews for Mecobion-NP Tablet SR















