Larentine D 5mg/10mg Tablet
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Strip of 10 tablets • TabletPrescription requiredSchedule H
Larentine D 5mg/10mg Tablet
Donepezil (5mg) + Memantine (10mg)
₹231.50
Strip of 10 tablets • Tablet
A valid prescription is required for this medicine.
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Active composition
Donepezil 5 mg
+1 more active ingredient
How It Works
Donepezil inhibits acetylcholinesterase, leading to increased acetylcholine availability at synapses and enhanced cholinergic transmission.
Memantine selectively blocks NMDA receptors, modulating glutamate activity and preventing excitotoxicity, which contributes to neuronal damage.
Medicine Strength
5 mg
All Active Ingredients
Donepezil5 mg
Memantine10 mg
Uses & Benefits
Medical applications
Headache
Larentine D 5mg/10mg Tablet is a combination pharmaceutical formulation containing Donepezil hydrochloride 5mg and Memantine hydrochloride 10mg, indicated for the treatment of moderate to severe Alzheimer’s disease. Donepezil, a reversible acetylcholinesterase inhibitor, enhances cholinergic function by increasing the concentration of acetylcholine in the brain, thereby improving cognitive function and memory.
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Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, modulates glutamatergic neurotransmission by blocking excessive NMDA receptor activity, which is associated with neurodegenerative processes. The synergistic action of these agents provides a dual mechanism targeting different pathways implicated in Alzheimer’s pathology, potentially offering improved efficacy over monotherapy.
Larentine D is administered orally, typically once daily, with dosage adjustments based on clinical response and tolerability. Common adverse effects may include headache, dizziness, gastrointestinal disturbances, and fatigue, which are generally mild to moderate in intensity. Caution is advised in patients with hepatic or renal impairment, and concurrent use with other cholinergic or NMDA-modulating drugs should be monitored closely.
Larentine D should be prescribed and used under medical supervision, with regular assessment of cognitive function and overall clinical status to optimize therapeutic outcomes.
Dosage & How to Use
How to use Larentine D Tablet Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Larentine D 5mg/10mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
Safety Advice
Important precautions
Side effects
Side-effect information is not available for this medicine. Please consult your doctor or pharmacist.
Safety Advice
Alcohol
It is unsafe to consume alcohol with Larentine D 5mg/10mg Tablet.
High Risk
Driving
Larentine D 5mg/10mg Tablet may cause side effects which could affect your ability to drive.
Exercise Caution
Liver
Larentine D 5mg/10mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Larentine D 5mg/10mg Tablet may be needed. Please consult your doctor.
Regular Checkup
Breastfeeding
Larentine D 5mg/10mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Consult Doctor
Kidney
Larentine D 5mg/10mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Larentine D 5mg/10mg Tablet may not be needed in these patients. Please consult your doctor.
Regular Checkup
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