Kronostar 500 Tablet CR
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Active composition
Sodium Valproate 333 mg
+1 more active ingredient
How It Works
Sodium Valproate increases GABAergic neurotransmission, stabilizing neuronal excitability and reducing seizure activity.
Valproic Acid increases GABA levels in the brain by inhibiting GABA transaminase, thereby reducing neuronal excitability and stabilizing electrical activity.
Medicine Strength
333 mg
All Active Ingredients
Sodium Valproate333 mg
Valproic Acid145 mg
Uses & Benefits
Medical applications
Migraine
Kronostar 500 Tablet CR contains Sodium Valproate (333 mg) and Valproic Acid (145 mg), providing a combined dose of 500 mg of active ingredients in a controlled-release formulation. This medication is primarily indicated for the management of epilepsy, including generalized and partial seizures, as well as bipolar disorder and migraine prophylaxis. Sodium Valproate and Valproic Acid act by increasing the availability of gamma-aminobutyric acid (GABA) in the brain, thereby exerting an inhibitory effect on neuronal excitability and stabilizing mood.
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The controlled-release mechanism ensures a sustained therapeutic plasma concentration, reducing dosing frequency and enhancing patient compliance. Kronostar 500 Tablet CR should be administered under medical supervision, with dosage individualized according to clinical response and tolerability. Common adverse effects may include gastrointestinal disturbances, weight gain, tremor, and sedation; serious but less frequent risks involve hepatotoxicity, pancreatitis, and hematological abnormalities.
Liver function tests and blood counts should be monitored regularly during therapy. This medication is contraindicated in patients with known hypersensitivity to valproate compounds, severe hepatic impairment, and urea cycle disorders. Caution is advised during pregnancy due to potential teratogenicity. Kronostar 500 Tablet CR is a valuable agent in the therapeutic arsenal for seizure control and mood stabilization, offering improved adherence through its controlled-release design.
Dosage & How to Use
Dosage information not available. Please consult your doctor or pharmacist.
Safety Advice
Important precautions
Side effects
Side-effect information is not available for this medicine. Please consult your doctor or pharmacist.
Safety Advice
Alcohol
Kronostar 500 Tablet CR is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
High Risk
Pregnancy
Kronostar 500 Tablet CR is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Medical Advice
Driving
Kronostar 500 Tablet CR is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Kronostar 500 Tablet CR may not be needed in these patients. Please consult your doctor. However, talk to your doctor if you have any underlying kidney disease.
Exercise Caution
Breastfeeding
Kronostar 500 Tablet CR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Consult Doctor
Kidney
Kronostar 500 Tablet CR should be used with caution in patients with liver disease. Dose adjustment of Kronostar 500 Tablet CR may be needed. Please consult your doctor. Use of Kronostar 500 Tablet CR is not recommended in patients with severe liver disease and active liver disease.
Regular Checkup
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