Jolyrab-DSR Capsule
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Domperidone (30mg) + Rabeprazole (20mg)
1 units • Other
A valid prescription is required for this medicine.
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Active composition
+1 more active ingredient
Rabeprazole irreversibly inhibits the H+/K+ ATPase enzyme in gastric parietal cells, reducing gastric acid secretion.
Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, inhibiting nausea and vomiting.
Medical applications
Jolyrab-DSR Capsule is a combination pharmaceutical formulation containing Domperidone 30 mg and Rabeprazole 20 mg, designed to manage gastrointestinal disorders characterized by acid reflux and delayed gastric emptying. Domperidone, a peripheral dopamine D2 receptor antagonist, enhances gastrointestinal motility by increasing the tone of the lower esophageal sphincter and accelerating gastric emptying, thereby alleviating symptoms such as nausea, vomiting, and bloating.
Rabeprazole, a proton pump inhibitor, suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells, providing effective relief from acid-related disorders including gastroesophageal reflux disease (GERD), erosive esophagitis, and peptic ulcers. The combined action of these agents offers symptomatic relief and promotes mucosal healing by reducing acid exposure and improving gastric motility.
Jolyrab-DSR is indicated for patients with GERD associated with delayed gastric emptying and other acid-peptic conditions requiring dual therapeutic intervention. It should be administered under medical supervision, considering contraindications such as hypersensitivity to components, and caution is advised in patients with cardiac arrhythmias or hepatic impairment. Adverse effects may include headache, dry mouth, abdominal cramps, and rare extrapyramidal symptoms.
Regular monitoring is recommended during prolonged therapy.
How to use Jolyrab-D Capsule SR Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Jolyrab-DSR Capsule is to be taken empty stomach.
Important precautions
Side-effect information is not available for this medicine. Please consult your doctor or pharmacist.
Caution is advised when consuming alcohol with Jolyrab-DSR Capsule. Please consult your doctor.
High Risk
Jolyrab-DSR Capsule may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
Jolyrab-DSR Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Exercise Caution
Jolyrab-DSR Capsule should be used with caution in patients with liver disease. Dose adjustment of Jolyrab-DSR Capsule may be needed. Please consult your doctor. Use of Jolyrab-DSR Capsule is not recommended in patients with moderate and severe liver disease.
Regular Checkup
Jolyrab-DSR Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Jolyrab-DSR Capsule should be used with caution in patients with kidney disease. Dose adjustment of Jolyrab-DSR Capsule may be needed. Please consult your doctor.
Regular Checkup
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