Isonise 10mg Capsule contains isotretinoin, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies, including antibiotics. Isotretinoin exerts its therapeutic effect by reducing sebaceous gland size and sebum production, inhibiting comedogenesis, and exerting anti-inflammatory properties, thereby addressing multiple pathogenic factors of acne. The recommended dosage should be individualized based on patient weight and clinical response, typically initiated at 0.5 mg/kg/day and adjusted up to 1 mg/kg/day as tolerated. Treatment duration generally spans 15 to 20 weeks or until clinical remission is achieved. Due to its teratogenic potential, strict pregnancy prevention measures must be enforced in women of childbearing potential, including negative pregnancy tests prior to initiation and monthly during therapy, alongside effective contraception. Common adverse effects include dry skin, cheilitis, conjunctivitis, and transient elevations in liver enzymes and lipid profiles; regular monitoring of hepatic function and lipid levels is advised. Isonise is contraindicated in pregnancy, hypersensitivity to isotretinoin, and patients with hypervitaminosis A. Patients should avoid vitamin A supplementation and minimize exposure to sunlight or UV rays during treatment. This medication should be prescribed and monitored by a healthcare professional experienced in isotretinoin therapy.

Dosage & How to Use