Intawin 400 Tablet contains Fluconazole 400 mg, an antifungal agent belonging to the triazole class, indicated for the treatment of various fungal infections. Fluconazole acts by inhibiting the fungal cytochrome P450 enzyme 14α-demethylase, which is essential for converting lanosterol to ergosterol, a critical component of the fungal cell membrane. This disruption leads to increased membrane permeability and ultimately fungal cell death. Intawin 400 is primarily prescribed for systemic and superficial fungal infections, including candidiasis (oropharyngeal, esophageal, and systemic), cryptococcal meningitis, and infections caused by susceptible strains of Candida and Cryptococcus species. It is also used for prophylaxis in immunocompromised patients at risk of fungal infections. The tablet is administered orally, with dosing adjusted based on the type and severity of infection, renal function, and patient response. Common adverse effects may include headache, nausea, abdominal pain, and rash, while serious side effects are rare but can involve hepatotoxicity and QT prolongation. Intawin 400 should be used cautiously in patients with liver impairment or those taking medications that interact with cytochrome P450 enzymes. Proper diagnosis and adherence to prescribed dosage are essential to ensure therapeutic efficacy and minimize resistance development.

Dosage & How to Use