Gliogen 20 Capsule
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Bottle of 5 capsules • CapsulePrescription requiredSchedule H
Gliogen 20 Capsule
Temozolomide (20mg)
₹1455.90
Bottle of 5 capsules • Capsule
A valid prescription is required for this medicine.
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Active composition
Temozolomide 20 mg
How It Works
Temozolomide methylates DNA, leading to the formation of DNA cross-links and inhibiting tumor cell proliferation.
Medicine Strength
20 mg
Uses & Benefits
Medical applications
HeadacheNausea
Gliogen 20 Capsule contains Temozolomide 20 mg, an oral alkylating agent primarily used in the treatment of certain types of brain tumors, including glioblastoma multiforme and anaplastic astrocytoma. Temozolomide is a prodrug that undergoes spontaneous conversion to its active metabolite, MTIC (monomethyl triazeno imidazole carboxamide), which exerts cytotoxic effects by methylating DNA at the O6 and N7 positions of guanine residues.
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This methylation leads to DNA strand breaks and apoptosis in rapidly dividing tumor cells. Gliogen 20 Capsule is indicated as a first-line treatment in combination with radiotherapy or as maintenance therapy following initial treatment. It is also used in recurrent cases where surgical options are limited. The medication is administered orally, allowing for convenient outpatient management.
Common adverse effects include myelosuppression, nausea, vomiting, fatigue, and headache, necessitating regular monitoring of blood counts and liver function during therapy. Contraindications include hypersensitivity to Temozolomide or dacarbazine and severe bone marrow suppression. Caution is advised in patients with hepatic or renal impairment. Gliogen 20 Capsule should be prescribed and monitored by oncology specialists experienced in chemotherapy management to optimize therapeutic outcomes and minimize toxicity.
Dosage & How to Use
Dacarbazine Derivative
Safety Advice
Important precautions
Side effects
Side-effect information is not available for this medicine. Please consult your doctor or pharmacist.
Safety Advice
Alcohol
Gliogen 20 Capsule is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
High Risk
Pregnancy
Gliogen 20 Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Medical Advice
Driving
Gliogen 20 Capsule is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Gliogen 20 Capsule may not be needed in these patients. Please consult your doctor. Cautious use is advised in patients with severe kidney disease while they are taking Gliogen 20 Capsule.
Exercise Caution
Breastfeeding
Gliogen 20 Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Consult Doctor
Kidney
Gliogen 20 Capsule should be used with caution in patients with severe liver disease. Dose adjustment of Gliogen 20 Capsule may be needed. Please consult your doctor. Limited information is available on the use of Gliogen 20 Capsule in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
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