ENPM Tablet
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Pregabalin (75mg) + Nortriptyline (10mg) + Methylcobalamin (1500mcg)
Strip of 10 tablets • Tablet
A valid prescription is required for this medicine.
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Active composition
+2 more active ingredients
Methylcobalamin acts as a cofactor in the synthesis of methionine from homocysteine, promoting nerve health and red blood cell formation.
Nortriptyline inhibits the reuptake of norepinephrine and serotonin, increasing their levels in the synaptic cleft and enhancing mood.
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels, inhibiting excitatory neurotransmitter release and reducing neuronal excitability.
Medical applications
ENPM Tablet is a combination pharmaceutical formulation containing Pregabalin 75 mg, Nortriptyline 10 mg, and Methylcobalamin 1500 mcg, indicated primarily for the management of neuropathic pain and associated neurological disorders. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, exerts its therapeutic effect by modulating calcium channels in the central nervous system, thereby reducing neuronal excitability and alleviating neuropathic pain.
Nortriptyline, a tricyclic antidepressant, enhances pain relief through inhibition of norepinephrine and serotonin reuptake, contributing to improved mood and analgesia. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair, promoting recovery in peripheral neuropathies. The synergistic action of these three components provides comprehensive management of chronic neuropathic conditions, including diabetic neuropathy, postherpetic neuralgia, and other nerve injury-related pain syndromes.
ENPM Tablet is typically administered orally as per physician’s prescription, with dosage tailored to individual patient needs and clinical response. Caution is advised in patients with renal impairment, cardiovascular disorders, or a history of hypersensitivity to any component. Adverse effects may include dizziness, dry mouth, sedation, and gastrointestinal disturbances. Regular monitoring and adherence to prescribed dosage ensure optimal therapeutic outcomes with minimal side effects.
Dosage information not available. Please consult your doctor or pharmacist.
Important precautions
Side-effect information is not available for this medicine. Please consult your doctor or pharmacist.
ENPM Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
High Risk
ENPM Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medical Advice
ENPM Tablet should be used with caution in patients with kidney disease. Dose adjustment of ENPM Tablet may be needed. Please consult your doctor.
Exercise Caution
ENPM Tablet may cause side effects which could affect your ability to drive. As ENPM Tablet may affect your alertness which may affect your ability to drive.
Consult Doctor
ENPM Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of ENPM Tablet may not be needed in these patients. Please consult your doctor.
Regular Checkup
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