Zeroscab Lotion contains Permethrin 5% w/v, an effective synthetic pyrethroid used for the treatment of scabies infestations caused by Sarcoptes scabiei var. hominis. Permethrin acts by disrupting the sodium channel current in nerve cell membranes of the mite, leading to delayed repolarization, paralysis, and eventual death of the parasite. Zeroscab Lotion is indicated for topical application in patients diagnosed with scabies, providing rapid relief from itching and preventing further transmission. The lotion should be applied thoroughly to the entire body from the neck down and left on for the recommended duration, typically 8-14 hours, before washing off. It is important to treat all close contacts simultaneously to avoid reinfestation. Zeroscab Lotion is generally well tolerated; however, mild local adverse reactions such as burning, stinging, or erythema may occur. It is contraindicated in individuals with known hypersensitivity to permethrin or any component of the formulation. Use in pregnant or breastfeeding women should be under medical supervision. Proper hygiene and environmental decontamination are advised to enhance treatment efficacy. Zeroscab Lotion offers a convenient and effective therapeutic option for managing scabies infestations with a favorable safety profile.