Zitlite 20 Capsule contains Isotretinoin 20 mg, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that has not responded to conventional therapies, including systemic antibiotics. Isotretinoin works by reducing sebaceous gland size and sebum production, inhibiting the growth of acne-causing bacteria, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. The capsule formulation ensures precise dosing and bioavailability. Due to its teratogenic potential, Zitlite 20 must be prescribed with caution, particularly in women of childbearing age, necessitating strict adherence to pregnancy prevention programs during treatment and for a specified period after discontinuation. Common adverse effects include dry skin, cheilitis, conjunctivitis, and transient elevations in liver enzymes and lipid levels; therefore, regular monitoring of liver function tests, lipid profile, and complete blood counts is recommended throughout therapy. Patients should avoid excessive sun exposure and use emollients to manage dryness. Zitlite 20 Capsule should be used under close medical supervision, with dosage adjustments based on clinical response and tolerability. It is contraindicated in pregnancy, hypersensitivity to isotretinoin, and patients with certain metabolic or hepatic disorders. Proper patient education on potential side effects and adherence to prescribed regimens is essential for optimal outcomes.