Zit 10 Capsule contains Isotretinoin 10mg, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics and topical agents. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting the growth of acne-causing bacteria, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. This medication is administered orally and should be used under strict medical supervision due to its well-documented teratogenicity and potential for serious adverse effects. Prior to initiation, patients must undergo baseline laboratory evaluations including liver function tests, lipid profile, and pregnancy testing for females of childbearing potential. Regular monitoring during therapy is essential to detect any hepatic or hematologic abnormalities. Common side effects include dry skin, cheilitis, and transient elevation of liver enzymes and lipids. Patients are advised to avoid vitamin A supplements and to use effective contraception throughout the treatment period and for at least one month after discontinuation. Zit 10 Capsule is contraindicated in pregnancy and in patients with hypersensitivity to isotretinoin or its components. This medication should be prescribed by dermatologists experienced in managing isotretinoin therapy to ensure optimal safety and efficacy.