Zitblow 20mg Soft Gelatin Capsule contains isotretinoin, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that has not responded to conventional therapies, including antibiotics. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting comedogenesis, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. Each capsule delivers 20mg of isotretinoin, administered orally, with dosing individualized based on patient weight and clinical response, typically ranging from 0.5 to 1 mg/kg/day divided into two doses. Treatment duration usually spans 15 to 20 weeks, with careful monitoring to minimize adverse effects. Common side effects include cheilitis, dry skin, and transient elevations in liver enzymes and lipid profiles; therefore, regular laboratory assessments are essential. Due to its teratogenic potential, strict pregnancy prevention measures must be implemented for female patients of childbearing potential, including negative pregnancy tests prior to and during therapy and effective contraception. Patients should avoid vitamin A supplements and use caution when exposed to sunlight or UV radiation. Zitblow should be prescribed and monitored by healthcare professionals experienced in isotretinoin therapy to ensure safety and efficacy.