Zit 20 Softgel Capsule contains Isotretinoin 20mg, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that has not responded adequately to conventional therapies such as antibiotics and topical agents. Isotretinoin, a derivative of vitamin A, acts by reducing sebaceous gland size and sebum production, normalizing follicular epithelial desquamation, and exhibiting anti-inflammatory properties. This multifaceted mechanism leads to a significant reduction in acne lesions and prevents the formation of new comedones and cysts. Zit 20 Softgel Capsule is administered orally, typically under the supervision of a dermatologist, with dosage individualized based on patient weight and clinical response. Due to its teratogenic potential, strict pregnancy prevention measures must be observed during treatment and for a specified period afterward. Common adverse effects include dry skin, cheilitis, and transient elevations in liver enzymes and lipid levels, necessitating regular monitoring of hepatic function and lipid profile. Patients should avoid vitamin A supplements and exposure to excessive sunlight or ultraviolet rays during therapy. Zit 20 Softgel Capsule represents an effective option for patients with severe acne, providing significant and sustained improvement when used in accordance with medical guidance.