Zipac 20mg Soft Gelatin Capsule contains isotretinoin, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics. Isotretinoin exerts its therapeutic effect by reducing sebaceous gland size and sebum production, inhibiting comedogenesis, and exerting anti-inflammatory properties, thereby addressing multiple pathogenic factors involved in acne development. Each capsule contains 20mg of isotretinoin, designed for oral administration with food to enhance absorption. The dosage regimen is individualized based on patient weight, severity of the condition, and clinical response, with treatment courses typically lasting 15 to 20 weeks. Due to its teratogenic potential, Zipac is contraindicated in pregnancy and requires strict adherence to pregnancy prevention programs during therapy. Common adverse effects include dry skin, cheilitis, conjunctivitis, and transient elevations in liver enzymes and lipid profiles, necessitating regular monitoring of hepatic function and lipid levels. Patients should be advised to avoid vitamin A supplementation and to report any signs of depression or mood changes promptly. Zipac 20mg Soft Gelatin Capsule should be prescribed and supervised by healthcare professionals experienced in acne management to ensure safe and effective use.