Zifi O 200mg/200mg Tablet is a combination antibiotic formulation containing Cefixime 200mg and Ofloxacin 200mg, designed for the treatment of a broad spectrum of bacterial infections. Cefixime, a third-generation cephalosporin, acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and death, while Ofloxacin, a fluoroquinolone, interferes with bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription. This synergistic action enhances antibacterial efficacy against both Gram-positive and Gram-negative organisms. Zifi O is commonly prescribed for respiratory tract infections, urinary tract infections, gastrointestinal infections, skin and soft tissue infections, and sexually transmitted infections caused by susceptible bacteria. The combination is particularly useful in cases where polymicrobial infections are suspected or when resistance to single-agent therapy is a concern. It is essential to use this medication under medical supervision to ensure appropriate dosing and duration, minimizing the risk of resistance development and adverse effects. Common side effects may include gastrointestinal disturbances, headache, dizziness, and hypersensitivity reactions. Patients with a history of hypersensitivity to cephalosporins or fluoroquinolones should avoid this medication. Renal and hepatic function should be monitored during prolonged therapy.