Zenitoin 10 Soft Gelatin Capsule contains isotretinoin 10 mg, a retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics and topical agents. Isotretinoin acts by reducing sebaceous gland size and sebum production, normalizing follicular epithelial desquamation, and exhibiting anti-inflammatory properties, thereby addressing multiple pathogenic factors of acne. Zenitoin 10 is administered orally and should be used under strict medical supervision due to its potential for serious adverse effects, including teratogenicity, hepatotoxicity, and lipid abnormalities. Baseline and periodic monitoring of liver function tests, lipid profile, and complete blood counts are recommended during therapy. Patients must adhere to pregnancy prevention programs, as isotretinoin is contraindicated in pregnancy due to the high risk of severe fetal malformations. Common side effects include dry skin, cheilitis, conjunctivitis, and photosensitivity. Dose adjustments may be necessary based on tolerance and clinical response. Zenitoin 10 should be prescribed only when the benefits outweigh the risks, with careful patient education on adherence, monitoring, and avoidance of vitamin A supplements or other retinoids. This medication is intended for use in adults and adolescents with severe nodular acne under specialist guidance.