Zenflox-Plus 200 Tablet is a combination antibiotic formulation containing Cefixime 200 mg and Ofloxacin 200 mg, indicated for the treatment of a broad spectrum of bacterial infections. Cefixime, a third-generation cephalosporin, exerts its antibacterial effect by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Ofloxacin, a fluoroquinolone antibiotic, inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication and transcription, resulting in bactericidal activity. The synergistic action of these two agents provides enhanced efficacy against both gram-positive and gram-negative pathogens, including resistant strains. Zenflox-Plus 200 is commonly prescribed for respiratory tract infections, urinary tract infections, otitis media, skin and soft tissue infections, and gonorrhea. It is essential to use this medication under medical supervision, adhering to the prescribed dosage and duration to prevent the development of resistance. Patients with a history of hypersensitivity to cephalosporins, fluoroquinolones, or any component of the formulation should avoid use. Caution is advised in individuals with renal or hepatic impairment. Common adverse effects may include gastrointestinal disturbances, headache, dizziness, and hypersensitivity reactions. Prompt medical consultation is recommended if severe side effects or allergic reactions occur.