Zaxdolin-NT Tablet is a combination pharmaceutical formulation containing Pregabalin 75 mg and Nortriptyline 10 mg, indicated for the management of neuropathic pain and certain chronic pain conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, exerts its therapeutic effect by modulating calcium channels in the central nervous system, thereby reducing the release of excitatory neurotransmitters and alleviating neuropathic symptoms such as burning, shooting pain, and allodynia. Nortriptyline, a tricyclic antidepressant, enhances analgesic efficacy through inhibition of norepinephrine and serotonin reuptake, contributing to mood stabilization and pain modulation. The synergistic action of these agents provides improved pain control in patients with diabetic peripheral neuropathy, postherpetic neuralgia, and fibromyalgia. Zaxdolin-NT is administered orally, with dosage tailored to individual patient response and tolerability. Common adverse effects may include dizziness, somnolence, dry mouth, and gastrointestinal disturbances; caution is advised in patients with a history of cardiac arrhythmias, glaucoma, or renal impairment. Due to potential central nervous system depressant effects, concurrent use with alcohol or other sedatives should be avoided. Regular monitoring and dose adjustments are recommended to optimize therapeutic outcomes and minimize adverse reactions. Zaxdolin-NT should be used under strict medical supervision.