NPM-Nerve Tablet SR is a sustained-release formulation combining Pregabalin 75 mg, Nortriptyline 10 mg, and Methylcobalamin 1500 mcg, designed for the management of neuropathic pain and associated conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channel activity in the central nervous system, thereby reducing neuronal excitability and alleviating neuropathic pain symptoms. Nortriptyline, a tricyclic antidepressant, exerts analgesic effects by inhibiting the reuptake of norepinephrine and serotonin, enhancing descending inhibitory pain pathways. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair through its role in myelin sheath maintenance and neuronal metabolism. The combination of these agents offers a multimodal approach, addressing both symptomatic relief and underlying nerve health. NPM-Nerve Tablet SR is indicated for peripheral neuropathies, diabetic neuropathy, postherpetic neuralgia, and other chronic neuropathic pain syndromes. The sustained-release formulation ensures prolonged therapeutic plasma concentrations, improving patient compliance and minimizing dosing frequency. Caution is advised in patients with renal impairment, cardiac conditions, or a history of seizures. Common adverse effects may include dizziness, somnolence, dry mouth, and gastrointestinal disturbances. Use under medical supervision is recommended to optimize efficacy and monitor for potential drug interactions.