Nuromet-NP Tablet SR is a sustained-release formulation combining Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated conditions. Pregabalin, an anticonvulsant and analgesic agent, modulates calcium channels to reduce neurotransmitter release, thereby alleviating neuropathic pain and improving nerve function. Nortriptyline, a tricyclic antidepressant, contributes to pain relief through inhibition of norepinephrine and serotonin reuptake, enhancing descending inhibitory pain pathways. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by promoting myelin sheath synthesis and neuronal metabolism. The combined action of these agents provides a multifaceted approach to neuropathic pain management, addressing both symptomatic relief and nerve health. Nuromet-NP Tablet SR is indicated for diabetic neuropathy, postherpetic neuralgia, peripheral neuropathy, and other chronic neuropathic pain syndromes. The sustained-release formulation ensures prolonged therapeutic plasma levels, improving patient compliance and minimizing dosing frequency. It should be used under medical supervision, with caution in patients with renal impairment, cardiovascular disorders, or those on concomitant CNS depressants. Adverse effects may include dizziness, somnolence, dry mouth, and gastrointestinal disturbances. Regular monitoring and dose adjustments are recommended to optimize efficacy and safety.