Lustre C Cream is a topical dermatological formulation containing Clindamycin 1% w/w and Tretinoin 0.025% w/w, indicated primarily for the treatment of acne vulgaris. Clindamycin, a lincosamide antibiotic, exerts its therapeutic effect by inhibiting bacterial protein synthesis, thereby reducing the proliferation of Propionibacterium acnes, a key pathogen implicated in acne pathogenesis. Tretinoin, a retinoid derivative of vitamin A, promotes keratinocyte differentiation and accelerates epidermal turnover, preventing the formation of comedones and facilitating the resolution of existing lesions. The combination of these active ingredients addresses both the inflammatory and comedonal components of acne, enhancing clinical efficacy. Lustre C Cream is typically applied once daily to the affected areas after cleansing, with caution advised to minimize irritation, dryness, or photosensitivity associated with retinoid use. Patients are recommended to use sunscreen during the day to prevent phototoxic reactions. The formulation is contraindicated in individuals with hypersensitivity to either component and should be used under medical supervision, especially in pregnant or lactating women. Overall, Lustre C Cream offers a synergistic approach to acne management, improving skin clarity and texture through antimicrobial and keratolytic mechanisms.