Levomac AZ Tablet is a combination antibiotic formulation containing Levofloxacin 500 mg and Azithromycin 500 mg, indicated for the treatment of a broad spectrum of bacterial infections. Levofloxacin, a fluoroquinolone antibiotic, exerts its antibacterial effect by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination, thereby preventing bacterial cell division and growth. Azithromycin, a macrolide antibiotic, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, leading to the suppression of bacterial growth. The synergistic action of these two agents provides enhanced efficacy against various susceptible gram-positive and gram-negative pathogens, including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and certain sexually transmitted infections. Levomac AZ is particularly useful in cases where monotherapy may be insufficient or resistance is a concern. It should be used under medical supervision, with dosage and duration tailored to the specific infection and patient condition. Caution is advised in patients with a history of hypersensitivity to fluoroquinolones or macrolides, and potential side effects include gastrointestinal disturbances, CNS effects, and QT interval prolongation. Regular monitoring is recommended during therapy to ensure safety and efficacy.