Lefuwise 20 Tablet contains Leflunomide 20 mg, an immunomodulatory agent primarily used in the management of active rheumatoid arthritis and psoriatic arthritis. Leflunomide acts by inhibiting dihydroorotate dehydrogenase, a key enzyme involved in pyrimidine synthesis, thereby reducing the proliferation of activated lymphocytes responsible for the inflammatory process. This mechanism helps to alleviate joint inflammation, pain, and swelling, ultimately improving physical function and slowing disease progression. Lefuwise 20 is indicated for adult patients with moderate to severe rheumatoid arthritis who have had an inadequate response to disease-modifying antirheumatic drugs (DMARDs). The recommended dosage is typically one 20 mg tablet daily, with or without food, as directed by a healthcare professional. Caution is advised in patients with hepatic impairment, and regular monitoring of liver function tests is recommended due to the potential risk of hepatotoxicity. Leflunomide is contraindicated in pregnancy due to its teratogenic effects and requires effective contraception during treatment and for an extended period after discontinuation. Common adverse effects include diarrhea, rash, alopecia, and elevated liver enzymes. Lefuwise 20 Tablet should be prescribed and used under strict medical supervision to ensure safety and efficacy.