Lefumide 10 Tablet contains Leflunomide 10 mg, an immunomodulatory agent primarily indicated for the treatment of active rheumatoid arthritis and psoriatic arthritis. Leflunomide acts by inhibiting dihydroorotate dehydrogenase, a key enzyme in pyrimidine synthesis, thereby reducing the proliferation of activated lymphocytes responsible for the inflammatory process. This mechanism helps to alleviate joint inflammation, pain, and swelling, ultimately improving physical function and slowing disease progression. Lefumide 10 is typically administered orally once daily, with or without food, under medical supervision. Prior to initiating therapy, baseline liver function tests and complete blood counts are recommended, as Leflunomide may cause hepatotoxicity and hematological abnormalities. Regular monitoring during treatment is essential to detect potential adverse effects early. Common side effects include diarrhea, rash, alopecia, and elevated liver enzymes. Lefumide 10 is contraindicated in patients with severe hepatic impairment, pregnancy, or hypersensitivity to Leflunomide. Due to its teratogenic potential, effective contraception is advised for both male and female patients during treatment and for a specified period afterward. Lefumide 10 offers a valuable therapeutic option for managing autoimmune arthritis by modulating immune response and improving patient quality of life.