Lefutoid 20 Tablet contains Leflunomide 20mg, a disease-modifying antirheumatic drug (DMARD) primarily indicated for the treatment of active rheumatoid arthritis and psoriatic arthritis. Leflunomide exerts its therapeutic effect by inhibiting dihydroorotate dehydrogenase, an enzyme involved in pyrimidine synthesis, thereby reducing the proliferation of activated lymphocytes responsible for inflammation and joint damage. This immunomodulatory action helps to alleviate symptoms such as joint pain, swelling, and stiffness, while also slowing disease progression and preventing structural joint damage. Lefutoid 20 is typically prescribed as part of a comprehensive treatment plan, often in combination with other antirheumatic agents or corticosteroids. The tablet should be administered orally, with or without food, as directed by a healthcare professional. Regular monitoring of liver function, blood cell counts, and blood pressure is recommended during therapy due to potential adverse effects including hepatotoxicity, immunosuppression, and hypertension. Patients should be advised to avoid pregnancy during treatment and for an extended period afterward due to teratogenic risks. Lefutoid 20 offers an effective therapeutic option for managing autoimmune arthritis conditions, improving patient quality of life through symptom control and disease modification.