Lacne 20 Softgel Capsule contains isotretinoin 20 mg, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that has not responded adequately to conventional therapies such as systemic antibiotics and topical agents. Isotretinoin works by reducing sebaceous gland size and sebum production, normalizing follicular keratinization, and exerting anti-inflammatory effects, thereby targeting multiple pathogenic factors of acne. Lacne 20 is administered orally, typically with food to enhance absorption, under strict medical supervision due to its significant adverse effect profile. Common side effects include dryness of the skin and mucous membranes, cheilitis, and photosensitivity. More serious risks involve teratogenicity, necessitating stringent pregnancy prevention measures before, during, and after treatment. Regular monitoring of liver function tests, lipid profiles, and complete blood counts is essential to detect potential hepatotoxicity, hyperlipidemia, and hematologic abnormalities. Patients should avoid vitamin A supplements and exercise caution when driving or operating machinery due to possible visual disturbances. Lacne 20 Softgel Capsule should be prescribed by dermatologists experienced in isotretinoin therapy, ensuring adherence to recommended dosing regimens and risk management programs to optimize therapeutic outcomes while minimizing adverse effects.