Jupinion 20 Tablet contains Isotretinoin 20 mg, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics and topical agents. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting comedogenesis, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. The medication is administered orally, with dosage individualized based on patient weight, severity of condition, and therapeutic response. Due to its potent teratogenicity, Jupinion 20 must be prescribed with strict adherence to pregnancy prevention protocols, including negative pregnancy tests prior to initiation and effective contraception during and after treatment. Common adverse effects include dry skin, cheilitis, mucosal dryness, and photosensitivity; more serious but less frequent risks involve hepatotoxicity, hyperlipidemia, and mood alterations. Regular monitoring of liver function tests, lipid profile, and complete blood counts is recommended throughout therapy. Patients should be counseled on avoiding vitamin A supplementation and limiting sun exposure. Jupinion 20 is contraindicated in pregnancy, lactation, and patients with hypersensitivity to isotretinoin or its components. This medication should be used under strict medical supervision to optimize efficacy and minimize potential risks.