Isotron 20 Softgel Capsule contains isotretinoin 20 mg, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics and topical agents. Isotretinoin works by reducing sebaceous gland size and sebum production, inhibiting comedogenesis, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors in acne development. The softgel formulation enhances bioavailability and ensures consistent dosing. Due to its teratogenic potential, Isotron 20 must be prescribed with strict adherence to pregnancy prevention programs, including effective contraception for female patients of childbearing potential. Regular monitoring of liver function tests, lipid profiles, and complete blood counts is recommended during therapy to detect potential adverse effects such as hepatotoxicity, hyperlipidemia, and hematologic abnormalities. Common side effects include dry skin, cheilitis, and photosensitivity, while rare but serious adverse reactions may involve psychiatric symptoms and musculoskeletal complaints. Isotron 20 Softgel Capsule should be used under close medical supervision, with dosing individualized according to patient response and tolerability. Patients are advised to avoid vitamin A supplementation and to report any unusual symptoms promptly. This medication is contraindicated in pregnancy and patients with hypersensitivity to isotretinoin or any capsule components.