Isotroin 20 Capsule contains isotretinoin 20 mg, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics and topical agents. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting the growth of acne-causing bacteria, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. The capsule is intended for oral administration under strict medical supervision due to its significant adverse effect profile and teratogenic potential. Patients prescribed Isotroin 20 must undergo regular monitoring, including liver function tests, lipid profiles, and pregnancy tests for women of childbearing potential. Common side effects include dry skin, cheilitis, photosensitivity, and transient elevations in liver enzymes and lipids. Due to its teratogenicity, effective contraception is mandatory during treatment and for at least one month after discontinuation. Isotroin 20 should be used with caution in patients with pre-existing liver disease, hyperlipidemia, or psychiatric disorders. This medication is contraindicated during pregnancy and lactation. Adherence to prescribed dosage and follow-up schedules is essential to maximize therapeutic benefits while minimizing risks.