Isoron 20 Capsule contains isotretinoin 20 mg, a potent retinoid indicated primarily for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies including systemic antibiotics. Isotretinoin acts by reducing sebaceous gland size and sebum production, normalizing follicular keratinization, and exhibiting anti-inflammatory properties, thereby addressing multiple pathogenic factors of acne. The capsule formulation ensures accurate dosing and optimal bioavailability. Isoron 20 should be administered under strict medical supervision due to its well-documented teratogenicity and potential for serious adverse effects such as hepatotoxicity, hyperlipidemia, and mucocutaneous reactions. Baseline and periodic monitoring of liver function tests, lipid profile, and complete blood count are recommended during therapy. Patients must adhere to pregnancy prevention programs, including the use of effective contraception before, during, and after treatment. Common side effects include dry skin, cheilitis, and photosensitivity, while rare but severe adverse events may involve psychiatric symptoms and musculoskeletal abnormalities. Isoron 20 Capsule is contraindicated in pregnancy, hypersensitivity to isotretinoin, and patients with pre-existing hepatic or lipid disorders. This medication should be prescribed and dispensed by healthcare professionals experienced in managing isotretinoin therapy to ensure safety and efficacy.