Isoperio 10mg Capsule contains isotretinoin, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics and topical agents. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting Propionibacterium acnes colonization, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. Each capsule delivers 10mg of isotretinoin, facilitating dose titration based on patient weight and clinical response. Administration should be under strict medical supervision due to its potent teratogenicity and potential adverse effects, including mucocutaneous dryness, elevated liver enzymes, hyperlipidemia, and possible mood alterations. Baseline and periodic monitoring of liver function tests, lipid profile, and complete blood counts are recommended during therapy. Female patients of childbearing potential must adhere to rigorous pregnancy prevention programs, including negative pregnancy tests prior to initiation and monthly during treatment. Isoperio is contraindicated in pregnancy, hypersensitivity to isotretinoin, and patients with severe hepatic or renal impairment. Patient counseling should emphasize adherence to prescribed dosing, avoidance of vitamin A supplements, and reporting of any psychiatric symptoms. Isoperio 10mg Capsule offers an effective option for severe acne management when used responsibly within a comprehensive treatment framework.