Isomento 20 Softgel Capsule contains isotretinoin 20 mg, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is resistant to conventional therapies such as systemic antibiotics and topical treatments. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting the growth of Propionibacterium acnes, and exhibiting anti-inflammatory properties, thereby addressing multiple pathogenic factors in acne development. The softgel formulation facilitates optimal bioavailability and ease of administration. Isomento 20 should be prescribed with caution due to its teratogenic potential and is contraindicated in pregnancy; effective contraception must be ensured in women of childbearing potential during treatment and for a specified period afterward. Common adverse effects include dry skin, cheilitis, conjunctivitis, and transient elevations in liver enzymes and lipid levels, necessitating regular monitoring of hepatic function and lipid profiles during therapy. Patients should be advised to avoid excessive sun exposure and use moisturizers to manage mucocutaneous side effects. Isotretinoin therapy requires careful patient selection, adherence to dosing guidelines, and close clinical supervision to maximize therapeutic outcomes while minimizing risks. Isomento 20 Softgel Capsule is supplied for oral administration under medical prescription only.