Isocret 20 Tablet contains isotretinoin 20 mg, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that has not responded adequately to conventional therapies such as antibiotics and topical agents. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting the growth of acne-causing bacteria, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. The medication is administered orally, with dosage individualized based on patient weight, severity of condition, and clinical response, typically over a course of 15 to 20 weeks. Due to its potent teratogenicity, strict pregnancy prevention measures must be implemented prior to and during treatment, including mandatory pregnancy testing and effective contraception for female patients of childbearing potential. Common adverse effects include dry skin, cheilitis, photosensitivity, and transient elevations in liver enzymes and lipid profiles, necessitating regular monitoring of hepatic function and lipid levels during therapy. Isocret 20 Tablet is contraindicated in patients with hypersensitivity to isotretinoin or its components, pre-existing liver disease, hyperlipidemia, and pregnancy. Patient education on adherence, potential side effects, and avoidance of vitamin A supplements is essential to optimize therapeutic outcomes and minimize risks.