Isoblink 10 Softgel Capsule contains isotretinoin 10 mg, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that has not responded adequately to conventional therapies such as antibiotics and topical agents. Isotretinoin acts by reducing sebaceous gland size and sebum production, normalizing follicular keratinization, and exhibiting anti-inflammatory properties, thereby addressing multiple pathogenic factors of acne. This medication is administered orally, with dosage individualized based on patient weight, severity of condition, and therapeutic response, typically ranging from 0.5 to 1 mg/kg/day. Due to its potent teratogenic effects, Isoblink 10 is contraindicated in pregnancy and requires strict adherence to pregnancy prevention programs in women of childbearing potential. Common adverse effects include dry skin, cheilitis, conjunctivitis, and transient elevations in liver enzymes and lipid profiles; therefore, regular monitoring of liver function tests, lipid levels, and complete blood counts is recommended during therapy. Patients should avoid excessive sun exposure and use appropriate skin moisturizers to manage dryness. Isoblink 10 Softgel Capsule should be prescribed and used under close medical supervision to ensure safety and efficacy in managing severe acne vulgaris unresponsive to other treatments.